Performance Nutrition & Thermoregulation

Overview

We conduct and are involved in a broad range of research and community outreach projects that encompass nutritional support for endurance exercise, metabolic buffering and supplementation, recovery strategies to support exercise performance, and strategies to mitigate heat stress. A number of our projects in this area are also in close collaboration with the ASU Athleat Field Lab directed by Dr Floris Wardennar and the Hydration Science Lab directed by Dr Stavros Kavouras, as well as Dr Jenni Vanos in the School of Sustainability.

Current Projects

Sodium bicarbonate supplementation & heat stress mitigation

Sodium bicarbonate supplementation, often used to offset the deleterious metabolic effects of intense exercise, has been widely researched in various capacities since the early 1900’s. Briefly, the kidneys produce the molecule bicarbonate (HCO3-), which in turn tightly regulates acid-base balance in the body and ultimately provides a “first line of defense” during high rates of metabolic flux (e.g., exertional, high intensity work or exercise). Although more commonly used in athletic scenarios to improve exercise performance, we’ve begun a series of investigations focused alternate uses of the supplement that are focused on potential thermoregulatory and renal benefits during prolonged physical activity in the heat.

Anthocyanins & exercise in hot environments

Anthocyanin, a type of polyphenol, is found abundantly in berries (e.g., New Zealand blackcurrant) and is the pigment responsible for coloring those that are blue and purple. In recent years, research has focused on anthocyanin’s efficacy as antioxidants and potential to promote health outcomes by reducing systemic inflammation. We have begun a line of research focused on exploring optimal dosing strategies, as well as investigating the effects anthocyanins may have on gut permeability during exercise in the heat.

Contrast therapy & functional recovery

The use of cold, hot and massage therapy modalities to improve physical recovery acutely and enhance human performance adaptation has existed for centuries, however recent evidence at the molecular level has questioned the appropriateness of these modalities in certain exercise contexts. For example, although cold therapy treatment reduces acute inflammation after trauma (e.g., ankle sprain) or exhaustive eccentric exercise (e.g., downhill running), it has been shown to blunt positive adaptation in skeletal muscle in instances of repeated application. Alternatively, heat application after exercise has shown promise in terms of facilitating greater cellular adaptations, but these have not consistently translated into exercise performance benefits. We are working on a series of industry-supported studies investigating the efficacy of different treatment modalities to improve functional recovery during training.

Relevant Publications, Conferences & Media

Publications

Wardenaar, F.C., Whitenack, L., Vento, K.A., Seltzer, R.G.N., Siegler, J., Kavouras, S.A. Validity of combined hydration self-assessment measurements to estimate a low vs. high urine concentration in a small sample of (tactical) athletes. Eur J Nutr. 63(1): 185-193, 2024. 2023 (doi: 10.1007/s00394-023-03254-1).

Rose, C., McGuire, H., Graham, K., Siegler, J., Fazekas de St Groth, B., Caillaud, C., Edwards, K. Partial body cryotherapy exposure drives acute redistribution of circulating lymphocytes: preliminary findings. Eur J Appl Phyisol. 123(2), 407-415, 2023 (doi: 10.1007/s00421-022-05058-3)

Siegler, J.C., Carr, A., Jardine, W., Convit, L., Cross, R., Chapman, D., Burke, L.M., Ross, M. The hyperhydration potential of sodium bicarbonate and sodium citrate. Int J Sport Nutr Exerc Metab. 32(2): 74-81, 2022 (doi: 10.1123/ijsnem.2021-0179).

Wardenaar, F., Armistead, S., Boeckman, K., Butterick, B., Youssefi, D., Thompsett, D., & Vento, K. Validity of Urine Color Scoring Using Different Light Conditions and Scoring Techniques to Assess Urine Concentration. J Athl Train, 57(2), 191– 198, 2022 (doi: 10.4085/1062-6050-0389.21.).

Conference Presentations

2023 Myth Busters in Sports Nutrition; American College of Sports Medicine (ACSM) Annual Meeting – PINES Special Interest Group, Denver, CO

2022 Integration of buffering agents into hyperhydration strategies prior to competing in the heat; European College of Sport Science (ECSS) Annual Meeting – Sports Nutrition Special Interest Group, Sevilla, ESP

2021 The efficacy of combining sodium bicarbonate and glycerol ingestion for the purposes of hyperhydration; American College of Sports Medicine Annual Meeting, Online (Thematic poster)

Media

The pill that over half the distance medallists used at the 2023 Worlds (Letsrun.com)

Pat’s Run - April 2024 ASU News